diff --git a/drivers/spi/spi-cadence-quadspi.c b/drivers/spi/spi-cadence-quadspi.c
index a8437d9c37a7..38518475858d 100644
--- a/drivers/spi/spi-cadence-quadspi.c
+++ b/drivers/spi/spi-cadence-quadspi.c
@@ -1531,6 +1531,10 @@ static bool cqspi_supports_mem_op(struct spi_mem *mem,
 			return false;
 		if (op->data.nbytes && op->data.buswidth != 8)
 			return false;
+
+		/* A single opcode is supported, it will be repeated */
+		if ((op->cmd.opcode >> 8) != (op->cmd.opcode & 0xFF))
+			return false;
 	} else if (!all_false) {
 		/* Mixed DTR modes are not supported. */
 		return false;